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KMID : 1144320100420030181
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감염과 화학요법
2010 Volume.42 No. 3 p.181 ~ p.186
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A Case of Cerebral Toxoplasmosis Following Tandem Autologous Stem Cell Transplantation in a Multiple Myeloma Patient
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Kim Kyae-Hyung
Song Kyoung-Ho
Park Wan-Beom
Kim Hong-Bin
Kim Nam-Joong
Oh Myoung-Don
Kim In-Ho
Jeon Jae-Hyun
Park Sang-Won
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Abstract
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Toxoplasmosis is a rare but fatal complication in hematopoietic stem cell transplant recipients, usually associated with allogeneic hematopoietic stem cell transplantation (HSCT). We report a case of cerebral toxoplasmosis in a patient with multiple myeloma, following tandem autologous stem cell transplantation. A 55-year-old Korean male presented with weakness in both legs that had progressed to both arms. A magnetic resonance imaging scan of the brain revealed multiple, variable-sized ring-enhancing lesions with surrounding edema in the cerebral hemispheres and brain stem. Stereotactic biopsy revealed bradyzoites of Toxoplasma gondii in the brain tissue. The patient received trimethoprim-sulfamethoxazole, followed by pyrimethamine and sulfadiazine, accompanying treatment for progressive multiple myeloma. Cerebral toxoplasmosis should be considered as one of the differential diagnoses in patients with neurologic signs following autologous HSCT.
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KEYWORD
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Toxoplasmosis, Cerebral, Stem cell transplantation, Autologous, Multiple myeloma
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